Radiation to Treat Joint Damage Caused by Cancer Immunotherapy

Exclusion Criteria

• •Contraindications to radiation treatment, such as pregnancy, breast-feeding women and active collagen-vascular disease.
• •Women of child-bearing potential who have positive urine or serum pregnancy test or refuse to do pregnancy test unless last menstrual cycle was \>1 year prior to consent and/or clear documentation states that the patient is peri- or post-menopausal or there was recent supporting objective evidence of 'no pregnancy' status (e.g. blood or imaging) within 30 days prior to initiation of study treatment.
• •Have not received systemic steroids within the last 3 months for the treatment of immune related adverse events.
• •History of prior autoimmune conditions, or concurrent immune related adverse events requiring systemic immunosuppressants.
• •Estimated life expectancy less than 3 months as assessed by investigators.
• •Any condition at the discretion of investigator that will preclude participation in the study.
• •History of secondary malignancy as assessed by investigators.
• •History of radiation to affected joints as assessed by investigators.