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Retinal Oxygen Metabolism in Children With Myopia | Clinical Trials | Clareo Health

NOT_YET_RECRUITING

Retinal Oxygen Metabolism in Children With Myopia

NCT07473401•Medical University of Vienna

Summary

The aim of the present study is to gain more information about retinal functional parameters in myopic children in Europe. For this purpose, a prospective case-control study in children aged between 8 and 13 years, as this is the usual age of myopia onset, will be conducted. Forty myopic children will be age- and sex-matched to non-myopic controls. Retinal oxygen extraction will be used as the main outcome parameter, as data from animal and human studies point towards an involvement of hypoxia in the disease process. In addition, other parameters probably linked to myopia will be investigated, such as retinal and choroidal blood flow as well as choroidal and retinal vessel density and anatomical structures such as choroidal and central retinal thickness. Also, questionnaires about lifestyle factors will be completed.

Eligibility

Age

8 - 13 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Children aged between 8 and 13 years (inclusive)
•Signed informed consent of child and legal guardian
•Normal ophthalmic findings except myopia
•Cycloplegic spherical equivalent (SE) refraction ≤ -1.0dpt in both eyes
•Normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant
•Children aged between 8 and 13 years (inclusive)
•Signed informed consent of child and legal guardian
•Normal ophthalmic findings
•Cycloplegic spherical equivalent (SE) refraction between +0.5dpt and -0.5dpt
•Normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant

Exclusion Criteria

•Intake of stimulating beverages containing xanthine derivatives (tea, coffee, cola-like drinks) 12 hours before the study day
•Previous eye abnormalities such as cataract, keratopathy, strabismus, amblyopia, ocular inflammation, trauma, or surgery
•History of any disease or syndrome associated with severe myopia such as Marfan syndrome, Stickler syndrome, or retinopathy of prematurity
•Non-axial cause of myopia
•BCVA less than 20/25
•Intraocular pressure ≥ 21mmHg
•Astigmatism ≤ -1.0dpt
•Anisometropia ≥ 2dpt
•Not able to read letters for visual acuity testing

Locations (1)

Department of Clinical Pharmacology, Medical University of Vienna, Austria

Vienna, Austria

Key Dates

Start Date

May 11, 2026

Primary Completion Date

January 2, 2027

Completion Date

January 2, 2027

Last Updated

March 16, 2026

Enrollment

ESTIMATED participants

Conditions

Myopia

Contacts

Doreen Schmidl-Schordje, MD, PhD

CONTACT

+43140400 29810 doreen.schmidl@meduniwien.ac.at

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 16, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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Retinal Oxygen Metabolism in Children With Myopia

Inclusion Criteria

Exclusion Criteria

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