Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

o Scheduled neurotoxic treatment in any of the following settings: Taxane cohort
Breast cancer patients planned for either neoadjuvant or adjuvant taxane treatment Oxaliplatin cohort
Rectal cancer patients planned for total neoadjuvant treatment including oxaliplatin
Colorectal cancer patients planned for adjuvant chemotherapy including oxaliplatin, without prior neoadjuvant oxaliplatin treatment
Understand written and oral Swedish.

Previous neurotoxic chemotherapy\* treatment
Distant metastases
Any psychiatric disorder or health disorder that causes an inability to make an informed consent to participate.
Any manifest clinically significant peripheral neuropathy according to treating physician.
Current lymphoedema in limbs requiring compression therapy.
Ongoing pregnancy.
Planned taxane or oxaliplatin treatment shorter than 8 weeks or longer than 26 weeks
Planned compression or cryotherapy of hands and/or feet during taxane or oxaliplatin
* Taxanes (docetaxel, paclitaxel, nabpaclitaxel), platinum components (carboplatin, oxaplatin, cisplatin), vinca-alkaloids (vincristine, vinblastine, vinorelbine, eribulin), bortezomid, thalidomide, antibody drug conjugate including vedotin or emtansine.

Compression Therapy of Hands and Feet for the Prevention of Taxane- or Oxaliplatin-induced Peripheral Neuropathy