NeuroCuple to Mitigate Post-Wisdom Teeth Extraction Opioid Risks

Exclusion Criteria

• •1. Children (\< 18 years of age)
• •2. T-score ≥ 60 in any of the three PROMIS measures (i.e., sleep, anxiety, and depression)
• •3. Other concomitant surgery being performed in addition to third molar extraction
• •4. History of gastrointestinal bleeding and/or peptic ulcer, renal disease (excluding kidney stones), hepatic disease, bleeding disorder, respiratory depression
• •5. History of respiratory depression with opioids or other anesthetic drugs that required postoperative ventilatory support or naloxone
• •6. Active or untreated asthma
• •7. Known allergy to ibuprofen, acetaminophen, oxycodone, hydrocodone, and/or anesthesia
• •8. Currently taking CYP3A4 inhibitors, azole-antifungal agents, protease inhibitors, or CNS depressants
• •9. Consumes three or more alcoholic drinks per day
• •10. Active alcoholism or illicit drug abuse (defined as daily use of illicit drugs)
• •11. History of substance or alcohol abuse
• •12. History of substance or alcohol abuse in a first-degree relative
• •13. No more than one opioid prescription filled within the past 12 months (self-report and PDMP)
• •14. Pregnant or lactating women