A Study to Investigate Stannous Fluoride Containing Toothpaste on Antibacterial Effects in the Different Regions of the Mouth

Exclusion Criteria

• •Participation in any other clinical study or test panel including clinical studies with oral hygiene formulations within the one month prior to entry into the study.
• •History of dental prophylaxis or treatments in the past month or during study duration.
• •History of medical treatments including antibiotic, anti-inflammatory or anticoagulant therapy during the month preceding study enrollment.
• •Subjects scheduled for medical procedures for the duration of the study.
• •Difficulty complying with study procedures and examinations such as excessive gagging during oral assessment etc.
• •History of significant adverse effects following use of oral hygiene products such as toothpastes and mouth rinses. Allergy to personal care/consumer products or their ingredients.
• •History of diabetes or hepatic or renal disease, or medical or inflammatory conditions or transmittable diseases, e.g. heart disease or AIDS.
• •History of rheumatic fever, heart murmur, mitral valve prolapse or other conditions requiring prophylactic antibiotic coverage prior to invasive dental procedures.
• •Oral soft tissue pathology.
• •History of active or severe periodontal disease and loose teeth.
• •Gross dental caries, severe generalized cervical abrasion and/or enamel abrasion, large fractured or temporary restorations (based on visual examinations).
• •Fixed or removable orthodontic appliance or removable partial dentures.
• •Self-reported pregnancy or lactation.
• •Subjects known to be an alcoholic, or a recovering alcoholic.