Personalized Antiemetic Regimen According to Patients' Pharmacogenetic Profile

Exclusion Criteria

• •Patient with advanced breast cancer.
• •Patient receiving cisplatin or any other chemotherapy of higher emetogenic potential, except for cyclophosphamide and doxorubicin in the regimens described above.
• •Patients who are scheduled to receive concurrent radiation as part of their chemotherapy regimen for their malignancy
• •Patients who experience any vomiting or grade 2-3 nausea per Common Terminology Criteria for Adverse Events version 4.0 (CTCAE v 4.03) in the 24 hours before Day 1 of chemotherapy
• •Patient has a history of treatment with moderately to highly emetogenic chemotherapy.
• •Patient has an active infection (e.g., pneumonia, systemic fungal infection) or any uncontrolled disease (e.g., diabetes mellitus, hypertension) which, in the opinion of the investigator, might confound the results of the study or pose unwarranted risk.
• •Patient with history of glaucoma, dementia, seizures, Parkinson's disease, Neuroleptic Malignant Syndrome (NMS), thromboembolic events.
• •Patient currently uses any illicit drugs, including marijuana, or has current evidence of alcohol abuse as determined by the investigator.
• •Patient is mentally incapacitated or has a significant emotional or psychiatric disorder that, in the opinion of the investigator, precludes study entry.
• •Patients who are regular alcohol drinker or smoker
• •Patient has a history of any illness that, in the opinion of the investigator, might confound the results of the study or pose unwarranted risk.
• •Patient has a history of hypersensitivity to aprepitant, ondansetron or dexamethasone.
• •Patients who have phenylketonuria and abnormal uric acid.
• •Any investigational drugs taken within 4 weeks prior to Day 1 of cycle 1, and/or is scheduled to receive any investigational drug during the study.