About Pricing FAQs Blog

Loading clinical trials...

Your health journey, clearly organized.

Find Clinical Trials →

Legal

Privacy Policy
Terms of Service

© 2026 Clareo Health. All rights reserved.

Back to clinical trial search

Not Yet RecruitingNANCT07444463

Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications

Previous and our studies have shown that cognitive impairments are core symptoms of three major psychiatric disorders-schizophrenia, bipolar disorder, and major depressive disorder, and are associated...

Lead sponsor: Central South University•1 locations•View source on ClinicalTrials.gov

Clareo plain-language summary

What this study is about

Generating AI summary...

Clareo turns complex medical information into clear understanding you can use.

Bring this clarity to your next appointment.

Keep all your medical notes and next steps in one place.

Contacts

Wenbin Guo, Ph.D.

CONTACT

+8673185360921 guowenbin76@csu.edu.cn

Sponsors

Lead Sponsor

Central South University

Age

18 - 60 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•1, For Patients (SZ, BD, MDD):
•Diagnosis of schizophrenia (SZ), bipolar disorder (BD), or major depressive disorder (MDD) according to standard diagnostic criteria
•First-episode drug-naïve patients or patients who have relapsed after discontinuing medication for more than one month
•Aged 18-60 years
•Completion of at least 6 years of formal education
•2, For Healthy Controls:
•Aged 18-60 years
•Completion of at least 6 years of formal education
•No current or past psychiatric disorders
•No first-degree relatives with psychiatric disorders
•No history of treatment with psychotropic medications or physical therapy for psychiatric disorders

Exclusion Criteria

•Prior use of psychotropic medications or receipt of physical treatment for psychiatric disorders (for patient group)
•Contraindications to MRI scanning
•History of brain injury
•History of substance abuse
•Presence of other neurological disorders
•Presence of severe medical or systemic physical illnesses.

Related studies

RECRUITINGPhase 3

A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine

NCT07140913 · Mania, Bipolar Disorder

RECRUITINGPhase 3

A Trial of the Efficacy and Safety of SEP-363856 in Acutely Psychotic Participants With Schizophrenia

NCT06894212 · Schizophrenia

RECRUITINGPhase 2

Dextromethorphan-Bupropion on Striatal Activity in Adults With Major Depressive Disorder

NCT07523048 · Major Depressive Disorder (MDD)

Accelerated Transcranial Magnetic Stimulation for People With Schizophrenia Treated With Clozapine

NCT06003036 · Schizophrenia, Schizoaffective Disorder

RECRUITINGPhase 2

Synbiotic Compound to Reduce Symptoms of Schizophrenia

NCT04226898 · Schizophrenia, Schizoaffective Disorder

View all related studies →

Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: March 4, 2026Terms

Trial snapshot

StatusNOT_YET_RECRUITING

PhaseNA

Enrollment400

Start dateJan 2027

Last updatedMar 4, 2026

Condition

Schizophrenia Bipolar Disorder Major Depressive Disorder (MDD)

Locations shown

Second Xiangya Hospital

Changsha, Hunan

For caregivers

Use Clareo to keep notes, questions, trial details, and next steps organized before and after appointments.

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 4, 2026Data synced to Clareo: May 10, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions