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Clinical Study to Assess the Efficacy of New Toothpaste Containing SnF as Compared to Colgate Cavity Protection Toothpaste on the Reduction of Enamel Erosion | Clinical Trials | Clareo Health

RECRUITINGPHASE3

Clinical Study to Assess the Efficacy of New Toothpaste Containing SnF as Compared to Colgate Cavity Protection Toothpaste on the Reduction of Enamel Erosion

NCT07442136•Colgate Palmolive

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn if a new toothpaste can prevent enamel erosion in healthy adults. Researchers will compare the test toothpaste to a control toothpaste to see if there is a difference in erosion levels. Participants will brush twice a day for two minutes with their assigned toothpaste.

Detailed Description

The objective of this clinical study is to assess the efficacy of New Toothpaste Containing SnF as compared to commercially available toothpaste in the reduction of enamel erosion over a ten (10) days period. This investigation will be a randomized, double-blinded, single-center, parallel clinical study. Subjects will be randomly assigned to one of the two study groups, and will be instructed to use their assigned toothpaste for a period of ten (10) days.

Eligibility

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Sign an Informed Consent Form;
•Male or female 18 to 70 years of age, inclusive;
•Be in good general health as determined by the study investigators;
•Available for the eighteen (18) days duration of the study;
•Have normal salivary flow rate (stimulated and unstimulated flow of ≥0.7 ml/min and ≥0.2 ml/min respectively) ascertained from a preliminary saliva examination;
•Have healthy salivary pH (unstimulated saliva pH 6.8-7.8) ascertained from a preliminary saliva test;
•Must be able to accept a well-fitting removable intraoral appliance bearing at least two enamel specimens.

Exclusion Criteria

•Gross oral pathology, chronic disease, and/or history of allergies to any of the test products;
•Use of a desensitizing oral care product and/or recipient of any dental desensitizing treatment within the past three months prior to start of the study;
•Advanced periodontal disease and/or treatment for periodontal disease (including surgery) within the past twelve months;
•Obvious signs of dental erosion Teeth with extensive/defective restorations (including prosthetic crowns), suspected pulpitis, caries, cracked enamel, or used as abutments for removable partial dentures;
•Current use of anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory drugs, daily use of analgesics, or medication which alters salivary flow
•Participation in any other oral clinical study for the duration of this study
•Self-reported pregnancy and/or currently breastfeeding;
•Allergies to oral care products, personal care consumer products, and/or their ingredients;
•Medical condition which prohibits not eating/drinking for 4 hours.

Locations (1)

School of Dentistry, University of Texas Health San Antonio

San Antonio, Texas, United States

Key Dates

Start Date

March 3, 2026

Primary Completion Date

April 1, 2026

Completion Date

April 1, 2026

Last Updated

March 18, 2026

Enrollment

ESTIMATED participants

Conditions

Enamel Erosion

Interventions

New Toothpaste Containing SnF

DRUG

Fluoride Toothpaste

DRUG