A Single-arm, Prospective, Phase II Clinical Study of the Combination of Entinostat and Oral Paclitaxel in the Treatment of HR+HER2- Advanced Breast Cancer
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Keep this study
Lead
Tianjin Medical University Cancer Institute and Hospital
Age
18–75
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Only participants who meet all of the following eligibility criteria will be eligible for this trial:
Age ≥ 18 years;
Patients with advanced breast carcinoma confirmed by histopathological and / or cytological examination;
HER2-negative breast carcinoma with confirmed HR positive primary and / or metastatic lesions;
At least one evaluable tumor lesion (according to RECIST1.1);
Prior 2-4 lines of therapy, which must include one endocrine therapy with CDK4 / 6 inhibitors, one chemotherapy with paclitaxel.
Previous 1L of ADC drug therapy is acceptable.
Complete clinical data on important research indicators;
The Eastern Oncology Assistance Group (ECOG) physical fitness status score was 0-2;
Life expectancy \> 6 months.
Clareo Health | A Single-arm, Prospective, Phase II Clinical Study of the Combination of Entinostat and Oral Paclitaxel in the Treatment of HR+HER2- Advanced Breast Cancer
