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Overnight Temporal Interference Stimulation of Bilateral Hippocampi to Reduce Epileptogenic Biomarkers and Improve Sleep in Temporal Lobe Epilepsy
The goal of this clinical trial is to gauge whether overnight, non-invasive temporal interference (TI) stimulation aimed at the hippocampus can reduce abnormal brain activity linked to seizures and improve sleep in adults with drug-resistant temporal lobe epilepsy. The main questions are: Does overnight TI stimulation lower seizure-related EEG activity during sleep? Does overnight TI stimulation improve sleep quality and sleep patterns measured overnight in the lab? Researchers will compare each participant's nights without stimulation to nights with active stimulation, and will also look at a night after stimulation ends to see whether any changes last. Participants will: Stay in-lab for six days for overnight sleep and EEG monitoring Have one night of monitoring without stimulation Receive TI stimulation during sleep for several nights Have another night of monitoring without stimulation after the stimulation nights Complete brief questionnaires and thinking/memory tasks before and after the stimulation nights Be checked for side effects and comfort during the study and at follow-up
Age
18 - 70 years
Sex
ALL
Healthy Volunteers
No
Anphy Lab - Inside Hock Plaza
Durham, North Carolina, United States
Start Date
May 1, 2026
Primary Completion Date
May 15, 2026
Completion Date
June 15, 2026
Last Updated
March 18, 2026
20
ESTIMATED participants
Non-invasive Temporal Interference (TI) Stimulation Targeting Bilateral Hippocampi
DEVICE
Lead Sponsor
Duke University
Collaborators
NCT01778504
NCT06430957
Data Source & Attribution
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