Loading clinical trials...

RECRUITINGNA

Comparison of Iliac Crest Marrow vs. Proximal Tibia Avitus® Bone Graft

NCT07434505•Mayo Clinic

Summary

The purpose of this research is to provide comparative data about the Avitus product and its equivalence to other Bone Marrow Aspirate (BMA) harvesting techniques.

Eligibility

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patient must be 18 years of age or older.
•Patient must be able and willing to sign the IRB approved informed consent.
•Patient must consent to preoperative knee and pelvis radiographs to confirm no issue at harvest location.
•Patient has indication for autograft bone harvest (undergoing any ankle or hindfoot fusion, complex mid and forefoot fusions requiring graft supplementation, treatment of fuse and fracture nonunions)
•Patient is indicated for proximal tibia autograft harvest and iliac crest BMA (e.g. no hx bilateral TKAs or previous iliac wing trauma bilaterally).
•Patient is skeletally "mature" and presents with no concern for osteopenia/osteoporosis.
•Patient has sufficient volume of harvest material for study inclusion (minimum of 10 ml of cancellous bone graft plus 10 ml fluid pressed out from cancellous bone portion)
•Patient must speak English or have access to sufficient translator.

Exclusion Criteria

•Patient is 70 yrs of age or older.
•Patient is unwilling or unable to give consent or comply with study protocol.
•Patient has any condition, which in the judgement of the Investigator, places the patient at undue risk or interferes with the study.
•Patient has mental or neurological disorder that will not allow for proper informed consent.
•Patient is known to be pregnant or breastfeeding.
•Patient is a vulnerable subject (prisoner, mentally incompetent or unable to understand what participation to the study entails, a known alcohol or drug abuser, and/or anticipated to be non-compliant).
•Patient has any condition, which in the judgement of the Investigator, may chemically skew bone marrow. This may include but is not limited to the following:
•* Cancer
•* Undergoing chemotherapy radiation,
•* Bone marrow transplant
+7 more criteria

Locations (1)

Mayo Clinic

Jacksonville, Florida, United States

Key Dates

Start Date

November 6, 2025

Primary Completion Date

December 1, 2026

Completion Date

December 1, 2026

Last Updated

February 25, 2026

Enrollment

ESTIMATED participants

Conditions

Bone Graft

Interventions

Avitus Bone Harvester

DEVICE

Contacts

Edward T Haupt, M.D.

CONTACT

904-953-2496 Haupt.Edward@mayo.edu

Mix of Demineralized Freeze-Dried Bone Allograft and Deproteinized Bovine Bone Mineral: a Possible Solution for Alveolar Ridge Preservation?

NCT06275789

Alveolar Ridge PreservationDental Extraction+1 more

View study

RECRUITINGNA

Radiographic Findings and Clinical Outcomes After Bone Grafting Patellar Defect in ACL Reconstruction

NCT06975306

Bone Graft; ComplicationsACL Injuries

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 25, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Comparison of Iliac Crest Marrow vs. Proximal Tibia Avitus® Bone Graft

Inclusion Criteria

Exclusion Criteria

Mix of Demineralized Freeze-Dried Bone Allograft and Deproteinized Bovine Bone Mineral: a Possible Solution for Alveolar Ridge Preservation?

Radiographic Findings and Clinical Outcomes After Bone Grafting Patellar Defect in ACL Reconstruction

Graft Maturity After Blood Flow Restriction Training in ACL Reconstruction

Resorbable vs Non-resorbable Bone Substitute at Immediate Post-extractive Single Implants

Evaluation of Hyaluronic Acid in Addition to Xenograft in Immediate Implant Placement Within Maxillary Esthetic Zone

Adding 1% Metformin Gel to Bone Graft in Association With Immediate Dental Implants