Biventricular or Left Bundle Branch Pacing to Assess the Effect of Cardiac Resynchronization Therapy in Patients Undergoing Transcatheter Aortic Valve Implantation

Mihály Ruppert

CONTACT

Annamaria Kosztin

CONTACT

Lead Sponsor

Semmelweis University Heart and Vascular Center

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Age over 18 years
•Successful and complication-free TAVI implantation for significant aortic stenosis
•Signed informed consent after detailed patient information
•New-onset LBBB wider than 130 ms after TAVI, persisting at the time of planned discharge (assessed postoperatively on or after day 5)(21)
•Mildly reduced left ventricular systolic function on echocardiography at the planned time of discharge (at the earliest on postoperative day 5), with EF between 35% and 55%

•Pre-existing right bundle branch block, or prior pacemaker/ICD implantation associated with significant (\>20%) ventricular pacing
•* Progression of LBBB during hospitalization to a degree indicating pacemaker implantation (e.g., Mobitz II or third-degree AV block, alternating bundle branch block) before the planned discharge date
•* Concomitant severe valvular disease of other valves (mitral, pulmonary, or tricuspid)
•* Severe infection and/or septic state
•* TAVI-associated stroke
•* More than moderate paravalvular leak of the TAVI valve on postoperative echocardiography
•* EF \< 35% or \> 55% on echocardiography performed at the planned time of discharge
•* GOLD stage IV COPD
•* Chronic renal failure requiring regular dialysis
•* Concurrent participation in another clinical trial