Impact of C-Mill Rehabilitation on the Gut-Brain Axis in Parkinson's Disease

Exclusion Criteria

• •PD patients with (1) weight \> 135 kg and Height \> 200 cm
• •Open lesions or bandages whether in contact with the harness of C-Mill strumentation
• •chronic gastro-intestinal (GI) disease including malabsorption;
• •clinical history of gastric lesions, gastro-resection or major intestinal surgery;
• •systemic and/or neurologic infectious, inflammatory, or autoimmune diseases of gastro-intestinal (GI) eg. Chron disease;
• •Acute GI phlogosis or GI disease in the last 4 weeks before recruitment;
• •Use of domperidone, or any drug potentially affecting gastrointestinal motility and integrity;
• •Use, in the last 4 weeks preceding the recruitment and until t2, of pre-probiotics or therapy based upon steroids, nonsteroidal anti-inflammatory drugs, antibiotics or antifungals;
• •anamnesis suggestive of GI cancer pathology.