A Study of VARIPULSE Catheter and TRUPULSE Generator With VARIPULSE Pro Software in Participants With PAF or PsAF

Exclusion Criteria

• •Continuous AF greater than (\>) 12 months (1-Year) (Longstanding Persistent AF)
• •Previous surgical or catheter ablation for atrial fibrillation
• •Any cardiac surgery within the past 2 months (60 days prior to consent date) (includes percutaneous coronary intervention \[PCI\])
• •Previous coronary artery bypass grafting (CABG) in conjunction with valvular surgery, cardiac surgery (for example, ventriculotomy, atriotomy) or valvular cardiac (surgical or percutaneous) procedure
• •Any carotid stenting or endarterectomy
• •Presence of left atrium (LA) thrombus
• •Severe dilatation of the LA (left atrial diameter \[LAD\] \>50 millimeters \[mm\] antero-posterior diameter in case of transthoracic echocardiography \[TTE\])
• •Severely compromised left ventricular ejection fraction (LVEF less than \[\<\] 40 percent \[%\])
• •Known significant pulmonary vein (PV) anomaly that in the opinion of the investigator would preclude enrollment in this study
• •Prior diagnosis of pulmonary vein stenosis
• •Pre-existing hemi diaphragmatic paralysis
• •History of blood clotting, bleeding abnormalities or contraindication to anticoagulation (heparin, warfarin, or dabigatran)
• •Myocardial infarction (MI) within the past 2 months (60 days prior to consent date)
• •Documented thromboembolic event (including transient ischemic attack \[TIA\]) within the past 6 months \[180 days prior to consent date\])
• •Rheumatic Heart Disease
• •Uncontrolled heart failure or New York heart association (NYHA) function class III or IV
• •Severe mitral regurgitation
• •Anticipated cardiac transplantation, cardiac surgery, or other major surgery within the next 12 months
• •Unstable angina pectoris within the past 6 months prior to consent date
• •Acute illness or active systemic infection or sepsis
• •Previously known AF secondary to electrolyte imbalance, thyroid disease, or reversible or non-cardiac cause (for example, documented obstructive sleep apnea, acute alcohol toxicity, morbid obesity \[Body Mass Index \>40 kilogram per meter square {kg/m\^2}\], renal insufficiency (with an estimated creatinine clearance \< 30 milliliters per minute {mL/min}/1.73 m\^2)
• •Presence of intracardiac thrombus, myxoma, tumor, interatrial baffle or patch, prosthetic valve or other abnormality that precludes catheter introduction or manipulation
• •Presence of intramural thrombus, tumor or other abnormality that precludes vascular access, or manipulation of the catheter
• •Presence of any other condition that precludes appropriate vascular access (such as inferior vena cava \[IVC\] filter)
• •Significant pulmonary disease, (for example, restrictive pulmonary disease, constrictive or chronic obstructive pulmonary disease \[COPD\]) or any other disease or malfunction of the lungs or respiratory system that produces chronic symptoms
• •Significant congenital anomaly or medical problems that in the opinion of the investigator would preclude enrollment in this study
• •Women who are pregnant (as evidenced by pregnancy test if pre-menopausal), lactating, or who are of childbearing age and plan on becoming pregnant during the course of the clinical investigation
• •Current enrollment in an investigational study evaluating another device, biologic, or drug
• •Presenting contra-indications for the devices used in the study, as indicated in the respective instructions for use (IFU)
• •Categorized as vulnerable population and requiring special treatment with respect to safeguards of well-being
• •Life expectancy less than 12 months
• •Contraindication for MRI such as use of contrast agents due to advanced renal disease, claustrophobia etc. (at principal investigator \[PI\] discretion)
• •Presence of iron-containing metal fragments in the body
• •Unresolved pre-existing neurological deficit