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Antimicrobial Effect of Calcium Silicate and Pectin as Intracanal Medications in Necrotic Teeth With Periapical Lesions | Clinical Trials | Clareo Health

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Antimicrobial Effect of Calcium Silicate and Pectin as Intracanal Medications in Necrotic Teeth With Periapical Lesions

Antimicrobial Effect of Calcium Silicate and Pectin as Intracanal Medications in Necrotic Teeth With Periapical Lesions :A Randomized Controlled Clinical Trial

NCT07423663•Suez Canal University

View on ClinicalTrials.gov

Summary

It is tackling antimicrobial resistance in endodontics, specifically comparing different intracanal medications used in root canal treatment. Given the growing concern over resistant bacterial strains, our study aims to evaluate the effectiveness of various medicaments in eliminating endodontic pathogens while minimising the risk of resistance development. By integrating microbiological analysis and clinical relevance, our research seeks to provide evidence-based recommendations for optimising intracanal disinfection protocols and improving treatment outcomes in endodontic infections.

Eligibility

Age

21 - 49 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Patients presenting with a single rooted mandibular premolar tooth with a closed apex and a single patent canal type I in Vertucci's classification (Vertucci et al., 1974).
•Having a necrotic pulp.
•A pocket depth measurement of \< 3 mm.
•Teeth with no previous history of endodontic treatment.
•Teeth with periapical lesions of endodontic origin having a periapical index score of 4 or 5 (Orstavik et al., 1986)
•Patients who took antibiotics within the period of three months before the study.
•Non-restorable teeth.
•Teeth with periodontal pockets deeper than 4mm, with or without concomitant or combined endo-perio communication
•Multirooted teeth.
•Previously initiated or treated teeth.
+6 more criteria

Locations (1)

Suez Canal University

Ismailia, Ismailia Governorate, Egypt

Key Dates

Start Date

September 1, 2024

Primary Completion Date

March 10, 2026

Completion Date

April 1, 2026

Last Updated

February 20, 2026

Enrollment

ACTUAL participants

Conditions

Asymptomatic Apical Periodontitis

Interventions

Calcium Hydroxide Intracanal medication

DRUG

Calcium silicate based intracanal medication

DRUG

Pectin

DRUG

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 20, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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