The GLUCID Study: Effect of Alcohol Reduction and Probiotic Interventions on Cognition and Brain Glucose Metabolism in Normal Aging Adults Who Are High-Risk Alcohol Drinkers
Able to provide valid informed consent, understand requirement and risk/benefits of the study and comply with study protocol
Heavy drinker defined as \>14 alcoholic drinks/week for men and \>7 drinks/week for women
Interested in reducing their alcohol consumption
You may not be if
BMI ≥ 35
Fasting Glucose \> 125 mg/dL
Current or previously diagnosed with Type 1 or 2 Diabetes
Requires the use of insulin and/or other glucose lowering agents
Unable to fast for 12 hours
Past serious alcohol withdrawal symptoms
MRI Contraindications (e.g., certain devices and implants, claustrophobic)
Diagnosed with a neurodegenerative disease (e.g., Alzheimer's Disease)
Diagnosed with a psychotic disorder
Current substance dependence diagnosis (except for mild or moderate alcohol)
Consumption of over 300 drinks in the past 30 days
Current probiotic use or recent probiotic use within the past 30 days
Current antibiotic use or recent antibiotic use within the past 30 days
In active cancer treatment and/or have advanced cancer
Taking daily steroids and/or immunosuppressants
Lifetime organ or bone marrow transplant; primary immunodeficiency (e.g., DiGeorge syndrome or Wiskott-Aldrich syndrome) or transplant recipient or prescribed immunosuppressant medications
PI's discretion
Clareo Health | The GLUCID Study: Effect of Alcohol Reduction and Probiotic Interventions on Cognition and Brain Glucose Metabolism in Normal Aging Adults Who Are High-Risk Alcohol Drinkers
