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RECRUITINGPHASE4

6-month Clinical Investigation Assessing the Efficacy of an Antimicrobial Mouthrinse in Reducing Established Plaque and Improving Gum Health

Clinical Investigation to Assess the Efficacy of an Antimicrobial Mouthrinse in the Reduction of Established Plaque and the Improvement of Gum Health: a 6-month Clinical Study

NCT07414173•Colgate Palmolive

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to evaluate the clinical efficacy of an antimicrobial mouthrinse, with a particular focus on its effect on established plaque and the improvement of gum health. Participants will: * Brush and rinse twice a day with the designated products for 6 months * Visit the clinic once every 3 months after baseline for reassessment.

Eligibility

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•1. Male and female subjects aged 18-70 years, inclusive.
•2. Availability for the 6-month duration of the clinical research study.
•3. Good general health based on the opinion of the study investigator.
•4. Signed Informed Consent Form.
•5. Minimum of 20 natural teeth (excluding third molars).
•6. Initial gingivitis index of at least 1.5 as determined by the use of the Loe and Silness Gingival Index.
•7. Initial plaque index of at least 1.5 as determined by the use of the Quigley and Hein Plaque Index (Turesky Modification).

Exclusion Criteria

•1. Be under orthodontic treatment.
•2. Presence of partial removable dentures.
•3. Tumor(s) of the soft or hard tissues of the oral cavity.
•4. Participants with current moderate or severe periodontitis (periodontitis screening index \[PSI\] \>2 in more than 2 sextants or PSI \>3), and/or purulent exudate, tooth mobility, and/or extensive loss of periodontal attachment or alveolar bone.
•5. Five or more carious lesions requiring immediate restorative treatment.
•6. Antibiotic use any time during the one-month period prior to entry into the study.
•7. Participation in any other clinical study or test panel within the one month prior to entry into the study.
•8. Dental prophylaxis during the past two weeks prior to baseline examinations.
•9. History of allergies to oral care/personal care consumer products or their ingredients.
•10. On any prescription medicines that might interfere with the study outcome based on the examiner/PI opinion.
+6 more criteria

Locations (1)

SGS proderm GmbH

Schenefeld, Germany

Key Dates

Start Date

January 28, 2026

Primary Completion Date

September 1, 2026

Completion Date

November 1, 2026

Last Updated

February 17, 2026

Enrollment

ESTIMATED participants

Conditions

GingivitisDental Plaque Accumulation

Interventions

Test Mouthrinse

OTHER

Control Mouthrinse

OTHER

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 17, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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6-month Clinical Investigation Assessing the Efficacy of an Antimicrobial Mouthrinse in Reducing Established Plaque and Improving Gum Health

Inclusion Criteria

Exclusion Criteria

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