Lead Sponsor

Albano Luigi

Collaborators

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•1. Diagnosis of NTSCI at least one year before presentation;
•2. Complete or incomplete spinal cord damage (ASIA grade A, B or C) conditioning chronic neuropathic pain and motor impairment;
•3. Age ≥ 18 years;
•4. Indication to spinal cord stimulation surgery for chronic pain;
•5. Being unable to stand or step independently;
•6. No current anti-spasticity medication regimen;
•7. No botox injections in the prior 3 months;
•8. Evidence of a personally signed and dated informed consent document indicating that the subject has been informed of all pertinent aspects of the study;
•9. Willingness and ability to comply with scheduled visits and other trial procedures.

•1. Any person unable to lie still within the environment of the MRI scanner for the required period to perform the study and those where MRI scanning is contraindicated;
•2. Pregnancy or breastfeeding;
•3. Any significant psychiatric disease;
•4. Use of illicit drugs;
•5. Unstable medical condition without cardiopulmonary disease or dysautonomia that would contraindicate standing or stepping;
•6. Painful musculoskeletal dysfunction, unhealed fracture, contracture, pressure sore, or urinary tract infection that might interfere with stand or step training;
•7. Spinal cord involvement above the D1 segment;
•8. Severe peripheral neuropathies or damage to the cauda equine.

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