Ozone Injection vs ESWT for Chronic Achilles Tendinopathy

Comparison of Ultrasound-Guided Local Ozone Injection and Extracorporeal Shock Wave Therapy in the Treatment of Chronic Achilles Tendinopathy

NCT07412652•Ankara City Hospital Bilkent

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Summary

This randomized controlled clinical trial compares ultrasound-guided local ozone injection, extracorporeal shock wave therapy, and conventional conservative treatment in patients with chronic Achilles tendinopathy. The study focuses on changes in pain, functional outcomes, and overall clinical improvement during the follow-up period.

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients aged 18 to 65 years.
•Patients with a diagnosis of Achilles tendinopathy confirmed by ultrasonography or magnetic resonance imaging (MRI).
•Patients with persistent symptoms despite completion of conservative treatment.
•Volunteers who agree to participate in the study.

Exclusion Criteria

•Patients with symptoms lasting less than 12 weeks.
•Presence of contraindications to extracorporeal shock wave therapy (ESWT), including pregnancy; history of thrombosis; use of anticoagulant medications; coagulation disorders such as hemophilia; systemic conditions; or localized conditions at the treatment site such as active infection or malignant tumors.
•Presence of contraindications to local ozone injection, including pregnancy; glucose-6-phosphate dehydrogenase (G6PD) deficiency; favism; uncontrolled hyperthyroidism; thrombocytopenia; severe cardiovascular conditions; and use of angiotensin-converting enzyme (ACE) inhibitors.
•History of neurological disease, muscle disease, or peripheral vascular disease.
•Presence of congenital or acquired deformities of the knee and/or ankle.
•Receipt of physical therapy modalities applied to the Achilles tendon within the last 6 weeks.
•Receipt of any therapeutic injection to the Achilles tendon within the last 12 weeks.
•History of direct trauma to the symptomatic Achilles tendon or Achilles tendon rupture.
•History of surgical treatment involving the Achilles tendon or ankle for any reason.
•History of foot or ankle dislocation or fracture within the past 1 year.
+3 more criteria

Locations (1)

Ankara Bilkent City Hospital - Physical Medicine and Rehabilitation Hospital

Ankara, Cankaya, Turkey (Türkiye)

Key Dates

Start Date

May 2, 2025

Primary Completion Date

January 2, 2026

Completion Date

January 15, 2026

Last Updated

February 17, 2026

Enrollment

ACTUAL participants

Conditions

Achilles Tendinopathy (AT)

Interventions

Ultrasound-Guided Local Ozone Injection

OTHER

Extracorporeal Shock Wave Therapy (ESWT)

DEVICE

Conventional Conservative Treatment

OTHER

Extracorporeal Shockwave Therapy and Platelet-Rich Plasma for Midportion Achilles Tendinopathy

NCT07483320

Achilles Injuries TendonAchilles Tendinopathy (AT)+4 more

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COMPLETEDNA

Eccentric Exercises Versus Heel Insole Lift for Achilles Tendinopathy in Football Players

NCT07360873

Achilles Tendinopathy (AT)

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 17, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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