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RECRUITINGNA

Remote Ischemic Conditioning Plus Stenting for Symptomatic Carotid Artery Stenosis

Remote Ischemic Conditioning Plus Stenting for Symptomatic Carotid Artery Stenosis (RICSICAS): A Prospective, Randomized Controlled, Blind Endpoint, Single-Center Study

NCT07412249•General Hospital of Shenyang Military Region

View on ClinicalTrials.gov

Summary

Remote ischemic conditioning (RIC) has emerged as a promising non-invasive strategy to protect the brain, with evidence suggesting its benefit in patients with carotid artery stenting (CAS). However, the long-term benefit and safety of chronic RIC in this population remain unknown. This trial aims to evaluate whether chronic RIC reduces the incidence of major vascular events and improves clinical outcomes in high-risk patients with carotid artery stenosis who received CAS.

Eligibility

Age

40 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Age ≥ 40 years old;
•Patients with symptomatic moderate to severe stenosis of the internal carotid artery;
•History of ipsilateral cerebral ischemic symptoms within the past 180 days;
•Planned for carotid artery stent;
•Essen Score ≥ 3;
•Modified Rankin Scale score of 0 or 1;
•Signed informed consent.

Exclusion Criteria

•Uncontrolled severe hypertension (systolic blood pressure \> 180 mmHg or diastolic blood pressure \> 110 mmHg despite medication)
•Subclavian artery stenosis ≥ 50% or presence of subclavian steal syndrome
•Severe hematological disorders or significant coagulation abnormalities
•Contraindications to remote ischemic conditioning, such as severe soft tissue injury, fracture, or vascular injury in the upper limbs, or peripheral vascular disease in the distal upper limbs
•Severe comorbid conditions with a life expectancy of less than 1 year
•Participation in another clinical trial within the past 3 months or ongoing participation
•Any other circumstances deemed by the investigator as unsuitable for participation in this clinical study.

Locations (1)

Department of Neurology, General Hospital of Northern Theater Command

Shenyang, China

Key Dates

Start Date

March 4, 2026

Primary Completion Date

November 30, 2027

Completion Date

November 30, 2027

Last Updated

March 9, 2026

Enrollment

300

ESTIMATED participants

Conditions

Carotid Stenosis

Interventions

Remote ischemic conditioning

DEVICE

Residual Stenosis and Restenosis Following Carotid Endarterectomy With Primary Closure, A Prospective Tracking Study

NCT07057297

Carotid ArteriosclerosisCarotid Stenosis+1 more

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ACTIVE_NOT_RECRUITING

Comprehensive Assessment of Atherosclerotic Ischemic Stroke Risk and Development of a Prediction Model

NCT06315153

Carotid StenosisIschemic Stroke

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 9, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Remote Ischemic Conditioning Plus Stenting for Symptomatic Carotid Artery Stenosis

Inclusion Criteria

Exclusion Criteria

Residual Stenosis and Restenosis Following Carotid Endarterectomy With Primary Closure, A Prospective Tracking Study

Comprehensive Assessment of Atherosclerotic Ischemic Stroke Risk and Development of a Prediction Model

Direct Access Carotid Artery Stenting Using the Neuroguard IEP System (PERFORMANCE III)

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