Vanessa Young, MS, BA, RN

CONTACT

Rylee Kerper, MPH

CONTACT

Lead Sponsor

Boston Children's Hospital

Age

0 - 0 years

Sex

ALL

Healthy Volunteers

No

•1. Infants born ≥36 weeks gestation.
•2. Any one of the following:
•1. sentinel event prior to delivery, such as uterine rupture, profound fetal bradycardia, or cord prolapse
•2. low Apgar scores (≤ 5 at 10 minutes of life)
•3. prolonged resuscitation at birth (chest compressions and/or intubation and/or mask ventilation at 10 minutes)
•4. severe acidosis (pH \< 7.0 from cord or neonate blood gas within 60 minutes of birth)
•5. abnormal base excess (≤ -16 mEq/L from cord gas or neonate blood gas within 60 minutes of birth)
•3. Moderate or severe encephalopathy present in the first 2 hours of life.
•4. Intubated and mechanically ventilated at the time of enrollment.

•1. Enrollment in the opt-out program.
•2. Presence of known cyanotic congenital heart disease.
•3. Presence of known or suspected genetic/chromosomal syndrome or multiple congenital anomalies.
•4. Presence of known congenital malformation that is expected to require urgent surgical intervention in the neonatal period, including congenital diaphragmatic hernia (CDH), gastroschisis, omphalocele, intestinal atresia, or imperforate anus.
•5. Presence of antenatally diagnosed central nervous system malformation, including hemorrhage, hydrocephalus, or structural anomaly of the brain (eg. polymicrogyria).
•6. Need for high frequency ventilation (HFV) at time of enrollment.
•7. Patients receiving respiratory support via Drager Babylog ventilators.
•8. Study enrollment and randomization after 2 hours of age