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Hyaluronic Acid and Amino Acid Combination Versus Exercise for Chronic Lateral Epicondylitis | Clinical Trials | Clareo Health

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Hyaluronic Acid and Amino Acid Combination Versus Exercise for Chronic Lateral Epicondylitis

A New Era in the Treatment of Chronic Lateral Epicondylitis: Comparison of Targeted Biological Support Using a Hyaluronic Acid and Amino Acid Combination Versus Exercise Therapy: A Retrospective, Controlled Clinical Study

NCT07410663•Sivas State Hospital

View on ClinicalTrials.gov

Summary

This retrospective, controlled clinical study aims to evaluate the effectiveness of a targeted biological support injection containing a hyaluronic acid and amino acid combination in patients with chronic lateral epicondylitis (tennis elbow). Medical records will be reviewed to compare outcomes between patients treated in routine clinical practice with a 3-dose injection regimen (weeks 0, 2, and 4) plus a home exercise program and those treated with a home exercise program alone. Key outcome measures include pain intensity (VAS), functional status (PRTEE), grip strength, and pressure pain threshold.

Eligibility

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients aged between 18 and 70 years.
•Patients diagnosed with Lateral Epicondylitis (LE).
•Presence of symptoms persisting for 6 weeks or longer.
•Patients who were treated with either a 3-dose protocol of Hyaluronic Acid + Amino Acid injection combined with a home exercise program, or a home exercise program alone.

Exclusion Criteria

•History of rheumatic disease.
•History of malignancy.
•Presence of radiculopathy or neuropathy.
•Presence of peripheral circulatory disorders.
•Congenital or acquired upper extremity deformities.
•History of coagulopathy or current use of warfarin therapy.
•Presence of prosthesis, metal implant, or internal fixator in the elbow region.

Locations (1)

Sivas State Hospital

Sivas, Turkey (Türkiye)

Key Dates

Start Date

December 1, 2025

Primary Completion Date

May 1, 2026

Completion Date

May 1, 2026

Last Updated

February 13, 2026

Enrollment

ESTIMATED participants

Conditions

Lateral Epicondylitis

Interventions

Hyaluronic Acid + Amino Acid Injection

DRUG

Home Exercise Program

BEHAVIORAL

Ultrasonographic Examination of Other Enthesitis Sites in Patients With Lateral Epicondylitis

NCT07314840

Lateral EpicondylitisLateral Elbow Tendinopathy (Tennis Elbow)

View study

RECRUITINGNA

Effects of Neuromuscular Reeducation Versus Friction Massage in Lateral Epicondylitis

NCT07004894

Lateral Epicondylitis

View study

RECRUITING

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 13, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Hyaluronic Acid and Amino Acid Combination Versus Exercise for Chronic Lateral Epicondylitis

Inclusion Criteria

Exclusion Criteria

Ultrasonographic Examination of Other Enthesitis Sites in Patients With Lateral Epicondylitis

Effects of Neuromuscular Reeducation Versus Friction Massage in Lateral Epicondylitis

Exercise Therapy and Orthoses in Lateral Elbow Tendinopathy: Comparative Effects

Neural Mobilization Exercises on Pain and Central Sensitization

Understanding Patient Preferences When Deciding on a Voluntary Musculoskeletal Test

The Effectiveness of the Combination of PRP and ESWT in Lateral Epicondylitis