Age

65–any

Sex

ALL

Healthy volunteers

Accepted

Age \> 65 years
MoCA scores 18-25 points
BMI of 20.0 - 29.9 kg/m2 at screening
Stable body weight (≤ 5% change) over the past 3-months
Willing to avoid consuming gut microbiome-modulating dietary supplements within 4 weeks prior to the baseline visit
Subjects will abstain from vitamin B2-rich food intake as per pre-defined list
Maintain current level of physical activity
Be willing and able to comply with trial protocol

Severe chronic disease and acute injuries
History of dietary supplement use four weeks before enrolment
Organic gastrointestinal (GI) disorders
Bowel surgery or short bowel syndrome
Gut-altering medications two months before enrolment
Is currently using systemic steroids, proton pump inhibitors, H2 blocker, antacid
History of drug and/or alcohol abuse at the time of enrolment
Smoker or vaper
Has made any major dietary changes in the past 3 months prior to baseline
Has a currently active eating disorder
Has food allergies or other issues with foods

Microbiome-Targeted Enhancement of Neurocognition With Probiotics-Riboflavin Combination