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Effect of Injectable Platelet Rich Derivatives on Orthodontic Canine Retraction | Clinical Trials | Clareo Health

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Effect of Injectable Platelet Rich Derivatives on Orthodontic Canine Retraction

The Effect of Injectable Platelet Rich Derivatives on the Rate of Orthodontic Canine Retraction: A Split-Mouth Randomized Controlled Trial

NCT07408895•Sana'a University

View on ClinicalTrials.gov

Summary

This study evaluated the effect of injectable platelet-rich derivatives on the rate of orthodontic canine retraction. Patients requiring orthodontic canine retraction following premolar extraction were enrolled and divided into three groups using a split-mouth design. Injectable platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) were applied to compare their effects on the rate of tooth movement. The outcomes were assessed by measuring the amount of canine retraction over time.

Eligibility

Age

17 - 29 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Healthy individuals aged 17-29 years (mean age 24 ± 6 years)
•Diagnosis of Class I bimaxillary protrusion or Class II division 1 requiring first premolar extractions
•Full permanent dentition
•Good oral hygiene
•Non-smokers
•Not taking medications affecting bone metabolism (e.g., bisphosphonates)

Exclusion Criteria

•Pregnancy or breastfeeding
•Contraindications to platelet therapies (e.g., platelet dysfunction)
•Severe malocclusion unsuitable for fixed appliances
•Dental anomalies (size/shape)
•Systemic syndromes

Locations (1)

Faculty of Dentistry, Sana'a University

Sanaa, Yemen

Key Dates

Start Date

May 30, 2024

Primary Completion Date

September 5, 2024

Completion Date

September 5, 2024

Last Updated

February 13, 2026

Enrollment

ACTUAL participants

Conditions

Accelerate Tooth Movement

Interventions

Platelet-Rich Plasma (PRP)

BIOLOGICAL

Platelet-Rich Fibrin (PRF)

BIOLOGICAL

The Effect of Corticotomy in En-mass Retraction

NCT03180151

Accelerate Tooth Movement

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 13, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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