LUNG-07: Advancing Precision-Based Lung Cancer Screening: Implementation, AI-Guided Risk Stratification, and Biomarker Integration (CREST AI)

Inclusion Criteria

• •Age 50-80 years at the time of consent
• •Meets at least one of the following LCS eligibility criteria:
• •* USPSTF: ≥20 pack-years, currently smoke or quit ≤15 years ago.
• •* Potter: 20 years of smoking, regardless of intensity
• •* ACS: ≥20 pack-years, no restriction on quit time
• •Receiving or scheduled for LDCT through the UI Health Lung Screening Program.
• •Willing to view a short (approximately 2-minute) educational video that explains Sybil AI scoring and LCS, complete the Sybil AI survey (if selected), and/or provide blood samples (optional).
• •Able to provide written informed consent and HIPAA authorization for release of personal health information, via an approved UIC IRB ICF and HIPAA authorization.
• •Women of childbearing potential must not be pregnant or breastfeeding. A negative serum or urine pregnancy test is required per institutional practice guidelines.
• •As determined at the discretion of the enrolling physician or protocol designee, the ability of the subject to understand and comply with study procedures for the entire length of the study