Pathophysiology of Dysautonomia and Postural Tachycardia Syndrome (POTS) in Post-viral Syndromes and COVID-19

Inclusion Criteria

• •Female participants aged ≥18 years
• •Diagnosis of idiopathic POTS (neuropathic form with evidence of neurodegeneration on skin biopsy) or Long COVID with or without POTS
• •Age-matched healthy controls with normal autonomic testing
• •Symptoms consistent with POTS: orthostatic intolerance ≥3 months with a clearly defined antecedent event (infection, travel, surgery)
• •Orthostatic tachycardia \>30 BPM without orthostatic hypotension, associated with reduced cerebral orthostatic blood flow and hypocapnia
• •Availability of electronic health record