The Effects of Rosuvastatin on Running Training Adaptation and Safety

Inclusion Criteria

• •Age ≥ 18 years.
• •Meets clinical criteria for statin therapy, including at least one of the following:
• •Family history of hyperlipidemia.
• •LDL-C ≥ 160 mg/dL.
• •10-year Atherosclerotic Cardiovascular Disease (ASCVD) risk ≥ 7.5%
• •Diabetes mellitus with LDL-C ≥ 70 mg/dL.
• •Determined by a clinician to require lipid-lowering therapy.
• •Currently using or eligible to initiate rosuvastatin therapy.
• •Performs long-distance running at least 3 times per week and is willing to maintain regular training for 3 months.
• •Able and willing to undergo cardiopulmonary exercise testing (CPET) and to record training data using a sports watch (for TRIMP calculation).
• •No known drug allergies and provides written informed consent after study explanation.