Albumin-bound Paclitaxel-based Second-line Treatment Regimens for Locally Advanced or Metastatic G/GEJ Adenocarcinoma

Exclusion Criteria

• •Patients with other malignancies within 5 years before enrollment, except for skin basal cell or squamous cell carcinoma after radical surgery, or cervical carcinoma in situ;
• •Patients who have received allogeneic bone marrow transplantation or organ transplantation in the past;
• •Patients with severe cardiovascular diseases within 6 months before enrollment, including unstable angina or myocardial infarction;
• •Patients allergic to the study drug or any of its auxiliary preparations;
• •Patients with uncontrolled hypertension before enrollment, defined as systolic blood pressure ≥ 150 mmHg and/or diastolic blood pressure ≥ 90 mmHg;
• •Patients with any disease or condition that affects drug absorption before enrollment, or patients who cannot take oral medication;
• •Patients with active ulcers in the stomach and duodenum, ulcerative colitis or other digestive tract diseases before enrollment, or unremoved tumors with active bleeding, or other conditions that the investigator deems may cause gastrointestinal bleeding or perforation;
• •Patients with obvious bleeding tendency evidence or history within 3 months before enrollment (bleeding \> 30 mL within 3 months, accompanied by hematemesis, melena, or hematochezia), hemoptysis (fresh blood \> 5 mL within 4 weeks), or thromboembolic events (including stroke events and/or transient ischemic attacks) within 12 months;
• •Patients with significant clinical cardiovascular diseases, including but not limited to acute myocardial infarction, severe/unstable angina or coronary artery bypass grafting within 6 months before enrollment; congestive heart failure with New York Heart Association (NYHA) classification \> 2; drug-treated ventricular arrhythmias; left ventricular ejection fraction (LVEF) \< 50%;
• •Patients with active or uncontrolled severe infections (≥ CTCAE v5.0 grade 2 infections);
• •Patients with known human immunodeficiency virus (HIV) infection. Patients with a history of clinically significant liver disease, including viral hepatitis \[known hepatitis B virus (HBV) carriers must exclude active HBV infection, i.e., HBV DNA positive (\> 1×104 copies/mL or \> 2000 IU/mL); known hepatitis C virus (HCV) infection and HCV RNA positive (\> 1×103 copies/mL)\];
• •Patients with any active autoimmune disease or a history of autoimmune disease (such as, but not limited to: autoimmune hepatitis, interstitial pneumonia, uveitis, enteritis, hepatitis, hypophysitis, vasculitis, nephritis, hyperthyroidism; patients with vitiligo; patients with childhood asthma that has completely resolved and does not require any intervention in adulthood can be included; patients with asthma requiring medical intervention with bronchodilators cannot be included); replacement therapy is not considered systemic treatment, the following patients can be included: those with a history of autoimmune-related hypothyroidism and receiving thyroid hormone replacement therapy; type 1 diabetes that can be controlled with insulin treatment;
• •Patients who have used immunosuppressants or systemic hormone therapy to achieve immunosuppression within 7 days before enrollment (dose \> 10 mg/day of prednisone or other equivalent efficacy hormones);
• •Patients with interstitial lung disease or pneumonia, pulmonary fibrosis, acute lung disease, or radiation pneumonitis;
• •Pregnant (positive pregnancy test before medication) or lactating women; Any other disease, clinically significant metabolic abnormalities, physical examination abnormalities or laboratory test abnormalities, as judged by the investigator, there is reason to suspect that the patient has a disease or condition that is not suitable for the use of the study drug (such as having epilepsy and requiring treatment), or will affect the interpretation of the study results, or put the patient at high risk;
• •Patients with urine routine indicating urine protein ≥ 2+ and 24-hour urine protein \> 1.0g;
• •Patients deemed unsuitable for inclusion in this study by the investigator.