Abscesses and Inflammatory Nodules (lesion) count ≥ 5
Inflammatory HS lesions in at least 2 different body regions, one of which must be Hurley Stage II or III
Inadequate response to at least one course of antibiotics
Topical antiseptics/washes are not required but allowed. If in use, the participant must agree to use one single product consistently through Week 16.
Use of oral antibiotics is allowed during the study under the following conditions: the dose and regimen must remain stable until Week 16. Allowed oral antibiotics include doxycycline, minocycline, or tetracycline.
Female participants of childbearing potential must have a negative pregnancy test
Participants of reproductive potential must use a highly effective method of contraception
You may not be if
\> 20 draining tunnel count
Active skin disease (bacterial, fungal, viral infection) that, in the opinion of the Investigator, could interfere with assessment of HS or requires treatment with antibiotic(s) also used to treat HS.
Has had major surgery, including HS surgery, within 12 weeks prior to Day 1
History of alcohol or drug abuse within the past 2 years.
A positive urine drug screen at Screening
History or evidence of human immunodeficiency virus (HIV), hepatitis B or hepatitis C virus (HCV), or a positive test at Screening
History or current diagnosis of active or latent pulmonary or extrapulmonary TB infection or a positive test at Screening
History of moderate to severe heart failure or recent (within past 6 months) cerebrovascular accident, myocardial infarction, or coronary stenting.
Any history of malignancy (including lymphoma and leukemia) other than a successfully treated and considered cured non-metastatic cutaneous squamous cell carcinoma, basal cell carcinoma or localized carcinoma in situ
History of immune deficiency
Clareo Health | A Study to Assess NAV-240 in Adult Participants With Hidradenitis Suppurativa
