IMRT Alone for Stage IB Nasopharyngeal Carcinoma Without High-Risk Features

Exclusion Criteria

• •1. Age \> 70 years or \< 18 years
• •2. Matted lymph nodes: two or more contiguous nodes with loss of intervening fat planes and/or extracapsular extension forming a confluent mass
• •3. Largest metastatic lymph-node ≥ 3 cm in the longest dimension
• •4. Lower-neck nodal metastasis: inferior border of any positive node below the inferior border of the hyoid bone
• •5. Prior malignancy except adequately treated basal-cell or squamous-cell carcinoma of the skin or carcinoma in situ of the cervix
• •6. Pregnancy or lactation (serum pregnancy test required for women of child-bearing potential; effective contraception mandatory during treatment)
• •7. Previous radiotherapy to the head-and-neck region
• •8. Prior chemotherapy or surgery for the primary tumour or metastatic nodes (diagnostic procedures excluded)
• •9. Any severe comorbidity that would confer unacceptable risk or compromise protocol adherence, including but not limited to unstable cardiac disease, renal failure, chronic hepatitis, or uncontrolled psychiatric disorder
• •10. History of severe hypersensitivity reactions