Have an AHI ≥ 15 on polysomnography (PSG) as part of the study at screening
Have a BMI ≥27 kg/m2 at screening
Have a stable body weight (\<5% body weight change) for 90 days prior to screening
Have a history of at least one self-reported unsuccessful dietary effort to reduce body weight
For YSA1 Participants:
Are unable or unwilling to use PAP therapy
For YSA2 Participants:
Have been on PAP therapy for at least three consecutive months prior to screening and plan to continue PAP therapy during the study
You may not be if
Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening)
Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
Any previous or planned surgery for sleep apnea or major ear, nose or throat surgery that still may affect breathing at time of screening
Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
Have had within 90 days prior to screening:
* acute myocardial infarction
* cerebrovascular accident (stroke)
* coronary artery revascularization
* unstable angina, or
* hospitalization due to congestive heart failure
Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
Have taken medications or alternative remedies intended for weight loss within 90 days of screening
