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Effect of Subthreshold Stimulation on Fatigue in Rheumatoid Arthritis | Clinical Trials | Clareo Health

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Effect of Subthreshold Stimulation on Fatigue in Rheumatoid Arthritis

Effect of Subthreshold Stimulation on Fatigability, Lower Limb Muscle Function and Strength, and Inflammatory Blood Markers in Patients With Rheumatoid Arthritis: A Randomized Controlled Study.

NCT07367438•Beni-Suef University

View on ClinicalTrials.gov

Summary

The study will include 2 groups. The study group will receive subthreshold stimulation, while the control group will receive sham treatment.

Detailed Description

This study will investigate the effect of subthreshold stimulation on fatigue-related parameters in patients with rheumatoid arthritis. This study will include 2 groups Study and the control group. The outcome measures will include Fatigability, Lower Limb Muscle Function and Strength, and Inflammatory Blood Markers. The measurements will be performed at the baseline, after 8 weeks, and after 12 weeks (follow-up).

Eligibility

Age

30 - 60 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Sixty patients with rheumatoid arthritis based on physician diagnosis and referral.
•* The patients' ages ranged from 30 to 55 (Tedeschi et al., 2013).
•* Body mass index ranged from 25-30 kg/m2.
•* Patients diagnosed with rheumatoid arthritis 5 years ago.

Exclusion Criteria

•Patients had chronic heart failure, cancer, chronic kidney disease, infection, and any other autoimmune disease (García-Morales et al., 2020).
•* Patients had unstable ischemic heart disease or arrhythmia (Lange et al., 2019).
•* Patients had joint surgery within 6 months before inclusion which did not allow them to perform physical activity as arthroplasty (Lange et al., 2019).
•* Patients had received biologics for RA treatments (Lange et al., 2019).

Key Dates

Start Date

February 15, 2026

Primary Completion Date

May 15, 2026

Completion Date

May 15, 2026

Last Updated

January 27, 2026

Enrollment

ESTIMATED participants

Conditions

Rheumatoid Arthritis (RA)

Interventions

Subthreshold stimulation

DEVICE

Sham treatment

OTHER

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 27, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Effect of Subthreshold Stimulation on Fatigue in Rheumatoid Arthritis

Inclusion Criteria

Exclusion Criteria

Clinical Cohort Construction and Therapeutic Effect Evaluation of Integrated Traditional Chinese and Western Medicine in the Treatment of Rheumatoid Arthritis

A Study to Evaluate the Safety and Activity of SAR448501/DR-0201 in Patients With Autoimmune Rheumatic Diseases

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