Acute Effects of a Urate-lowering Bacterial Therapeutic on Small Intestinal Transcriptomics and Glycomics in Healthy Subjects

Exclusion Criteria

• •Chronic GI, inflammatory, metabolic (including renal), or significant psychiatric disease.
• •Acute infection/allergy within 2 weeks.
• •Regular use of NSAIDs, antibiotics, steroids, immunomodulators.
• •Alcohol \>9 units/week.
• •Use of recreational drugs, tobacco, or nicotine.
• •Known allergy to local anesthetics or sedatives for gastroscopy.
• •Bleeding disorder or use of anticoagulants.
• •Use of probiotics or antibiotics within 4 weeks prior.
• •Pregnancy, breastfeeding, or planning pregnancy.
• •Any condition deemed by investigator to compromise safety or data integrity