Efficacy and Safety of Intra-Arterial Albumin as Adjunct to Mechanical Thrombectomy in Acute Ischemic Stroke

Exclusion Criteria

• •Intracranial hemorrhage confirmed by cranial CT or MRI
• •Midline shift with significant mass effect on cranial CT or MRI
• •Isolated internal carotid artery (ICA) occlusion
• •History of heart failure or severe cardiovascular disease, including but not limited to pulmonary hypertension or pericardial effusion
• •Hemodynamically unstable arrhythmia (based on patient self-report or detected prior to infusion)
• •Symptoms or electrocardiographic evidence of acute myocardial infarction upon admission
• •Acute or chronic renal failure (serum creatinine \>2.0 mg/dL
• •Severe anemia (hematocrit \<32%
• •Known hypersensitivity to albumin or blood products
• •Pregnancy
• •Persistent hypertension (blood pressure ≥180/100mmHg) prior to albumin infusion
• •Current participation in other clinical trials
• •Life expectancy of less than 3 months
• •Concomitant severe pulmonary disease, such as chronic obstructive pulmonary disease, pulmonary fibrosis, pleural effusion, or acute respiratory distress syndrome
• •Any other condition that, in the opinion of the investigator, renders the patient unsuitable for participation in the study