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The goal of this clinical trial is to investigate the efficacy, durability, and safety of aflibercept 8 mg in treating Polypoidal Choroidal Vasculopathy (PCV) in Chinese naive patients. The main questions it aims to answer are: 1. What is the change in Best Corrected Visual Acuity (BCVA) at Week 52 from baseline in different treatment regimens? 2. What proportion of patients achieve sustained disease control after receiving the loading dose? Participants will: * Receive intravitreal aflibercept 8 mg loading doses (3 initial monthly doses). * In Arm A: * Undergo reinjections based on disease activity, with follow-up examinations every 4 weeks until week 48. * Return for an end-of-study visit at week 52. * In Arm B: * Undergo an examination at week 12 and subsequent treatments based on disease activity, with a maximum interval of 20 weeks and a minimum interval of 8 weeks between doses if the disease remains inactive. * Return for an end-of-study visit at week 52. This study will assess the efficacy, safety and durability of aflibercept 8mg in these 2 regimens.
Age
50 - No limit years
Sex
ALL
Healthy Volunteers
No
Beijing Hospital
Beijing, Beijing Municipality, China
Beijing Tongren Hospital, CMU
Beijing, Beijing Municipality, China
The Second People's Hospital Of Foshan
Foshan, Guangdong, China
The First Affiliated Hospital Of Harbin Medical University
Harbin, Heilongjiang, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Renmin Hospital Of Wuhan University
Wuhan, Hubei, China
Jiangsu Province Hospital , The First Affiliated Hospital with Nanjing Medical University
Nanjing, Jiangsu, China
Affiliated Eye Hospital of Nanchang University
Nanchang, Jiangxi, China
The Second Norman Bethune Hospital Of Jilin University
Jilin, Jilin, China
Xi' AN No.1 Hospital
Xi'an, Shaanxi, China
Start Date
January 1, 2026
Primary Completion Date
December 31, 2027
Completion Date
December 31, 2027
Last Updated
January 26, 2026
174
ESTIMATED participants
Aflibercept Intravitreous Injection
DRUG
Lead Sponsor
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Collaborators
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
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