Pancreas Lipotoxicity in T2D: Edinburgh Diabetes Remission Study (EDRS)

Inclusion Criteria

• •Overweight/obese (BMI: 30-45 kg/m²) who have had T2D for less than 6 years or longer than 10 years, and are on treatment with diet alone or diet plus oral medication.
• •Overweight/obese (BMI: 30-45 kg/m²) who are at pre-diabetes stage, defined as fasting blood glucose 5.6-6.9 mmol/L.
• •Overweight/obese (BMI: 30-45 kg/m²) who are non-diabetic (control group).
• •Age between 45 and 79 years inclusive.
• •Post-menopausal women only (to exclude sex hormone effects on lipid metabolism).
• •Good communication in English (able to give informed consent and follow dietary advice).
• •Willing and able to adhere to the study protocol, including dietary intervention and scheduled follow-up visits.