Prevention of Reperfusion Injury Outcomes Through Effective Cardioprotection Targeting Myocardial Infarction

Exclusion Criteria

• •History or ECG evidence of myocardial infarction or cardiomyopathy.
• •Prior major cardiac surgery, including but not limited to coronary artery bypass graft surgery (CABG).
• •Known contraindication to CMR (e.g. pacemakers, cochlear implants, aneurism clips, claustrophobia, allergy to contrast medium).
• •History of clinically significant renal impairment requiring dialysis or an estimated glomerular filtration rate \<30 mL/min.
• •Estimated or known body weight \< 50 kg, \> 120 kg at screening.
• •Concurrent enrolment in another investigational device or drug trial, or less than 30 days or 5 half-lives of investigational device or drug (whichever is longer), since ending another investigational device or drug trial(s) or receiving other investigational treatment(s). Patients who are participating in non-interventional, purely observational trials can be included.
• •Life expectancy of less than 1 year due to non-cardiac pathology in the opinion of the Investigator.
• •Any condition or significant clinical abnormality identified at the time of screening that in the judgment of the Investigator or any sub-Investigator would preclude safe completion of the study.
• •Known history of hypersensitivity to the investigational drug, or excipients, or do not want to be exposed to soy or egg (including products and derivatives).