Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Adults aged 18 years and older.
Patients with periampullary neoplasms requiring pancreaticoduodenectomy, including but not limited to:
Pancreatic adenocarcinoma
Distal bile duct adenocarcinoma
Duodenal adenocarcinoma
Leiomyosarcoma of the duodenum
Pancreatic neuroendocrine neoplasms
Ampullary adenoma
Duodenal gastrointestinal stromal tumor
High-risk intraductal papillary mucinous neoplasm according to Fukuoka criteria, specifically focal Intraductal Papillary Mucinous Neoplasm (IPMN) in the head of pancreas with high-risk stigmata or worrisome features on endoscopic ultrasound with fine-needle aspiration
Mucinous cystic neoplasm
Serous cystadenoma
Soft pancreatic gland and main pancreatic duct ≤2 mm at the neck of the pancreas based on preoperative imaging.
Adequate islet function with measurable C-peptide preoperatively to justify islet isolation and transplant.
You may not be if
Pregnancy.
Active alcohol or illicit drug use.
Poorly controlled psychiatric illness that limits ability to comply with care.
Pre-existing insulin-dependent diabetes with absent C-peptide.
Portal vein thrombosis or significant portal hypertension precluding islet infusion.
