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Probiotics Regulate Intestinal Health and Alleviate Anxiety | Clinical Trials | Clareo Health

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Probiotics Regulate Intestinal Health and Alleviate Anxiety

Effects of Probiotics on Alleviating Anxiety and Depression and Gut Microbiota

NCT07353320•Wecare Probiotics Co., Ltd.

Summary

This study is a randomized, double-blind, placebo-controlled trial aimed primarily at investigating the effects of Weizmannia coagulans BC99 on alleviating anxiety and depression and the gut microbiota.

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•1. Adults aged 18-65 years.
•2. Individuals experiencing scientific research, employment-related, or occupational stress, including graduate students or community-dwelling adults with job-related pressure.
•3. A Hamilton Depression Rating Scale (HAMD-17) score ≥ 8 and/or a Hamilton 4) Anxiety Rating Scale (HAMA-14) score ≥ 7 at screening.
•5)Ability and willingness to voluntarily participate in the study and to provide written informed consent prior to enrollment.

Exclusion Criteria

•1. A confirmed previous diagnosis of other psychiatric disorders, including intellectual disability, bipolar disorder, treatment-resistant depression, or suicidal ideation.
•2. Pregnant or breastfeeding women.
•3. Individuals with known food or drug allergies, or those with alcohol abuse or psychotropic substance abuse.
•4. Use of antibiotics or probiotics known to affect gut microbiota for more than one week within one month prior to enrollment.
•5. Participants who withdrew from the study, discontinued intervention, or were unable to complete the study for any reason.

Locations (1)

Henan University of Science and Technolog

Luoyang, Henan, China

Key Dates

Start Date

April 10, 2024

Primary Completion Date

June 5, 2024

Completion Date

April 1, 2025

Last Updated

January 20, 2026

Enrollment

ACTUAL participants

Conditions

Anxiety Depression

Interventions

probiotics group

DIETARY_SUPPLEMENT

Placebo Group

DIETARY_SUPPLEMENT

Group Therapy Using the "I-Reconstruction" Psychotherapy Method to Reduce Anxiety Levels

NCT07397429

AnxietyAnxiety Depression

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RECRUITING

CBT and the Neural Circuits of Anxiety

NCT05549102

Generalised Anxiety DisorderAnxiety Disorders+7 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 20, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Probiotics Regulate Intestinal Health and Alleviate Anxiety

Inclusion Criteria

Exclusion Criteria

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