Written informed consent; able and willing to comply with study procedures.
Adults with documented COPD diagnosis and medical history consistent with guideline criteria.
Relevant exposure history consistent with COPD (e.g., smoking).
On stable, guideline-based maintenance COPD therapy prior to randomization, per investigator judgment.
Protocol-defined exacerbation history, symptom burden, and lung function at screening.
You may not be if
Current or past asthma, or other clinically significant respiratory disease that may confound assessment.
Clinically significant uncontrolled comorbidities that increase risk or interfere with participation/outcomes.
Immunodeficiency/immune dysregulation, active autoimmune disease requiring systemic immunosuppression, or significant opportunistic infection history.
Active clinically significant infection or recent infection requiring systemic therapy; recent protocol-defined COPD exacerbation.
Current/recent malignancy (except low-risk, adequately treated cancers per protocol) or clinically significant abnormal screening labs.
Prohibited recent vaccines or therapies, prior relevant biologic/targeted therapy exposure, severe hypersensitivity to biologics/IMP, - pregnancy/breastfeeding, or inability to comply (including substance abuse), per investigator judgment.
