Newly diagnosed patients: Unifocal, unilateral high-grade glioma based on MRI
Recurrent patients: First radiological progression (as determined by the multidisciplinary team \[MDT\]) of GBM previously treated with standard care surgery and chemoradiotherapy. Patients must have a prior confirmed histological/molecular diagnosis of GBM
Newly diagnosed patient: suitable for six weeks of chemoradiotherapy followed by six months of adjuvant temozolomide (Stupp protocol)
Debulking surgery is indicated for optimal patient care
Able to swallow oral medication
Willing to avoid live vaccines
Adequate organ function
Female patients of childbearing potential must have a negative serum pregnancy test within 7 days prior to Day 0.
All patients must agree to practice true abstinence or to use highly effective contraception
Patient is willing and able to give informed consent for participation in the study
You may not be if
Patient who is pregnant, lactating or planning pregnancy during the course of the study
Immunodeficiency or active auto-immune disease requiring systemic therapy.
Active viral, bacterial or fungal infection requiring concurrent antivirals or antibiotics within 7 days of surgery
Live vaccine within 28 days prior to Day 0
Use of immunosuppressant or immune modulatory medicines within 28 days prior to Day 0
History of tuberculosis infection or chest x-ray or computed tomography (CT) chest showing radiological evidence of previous tuberculosis infection
Received previous treatment with a gene therapy
Significant history of a central nervous system disorder that, in the opinion of the Investigator, would preclude enrolment
Major surgery within 28 days prior to Day 0. A stereotactic biopsy is permitted
Known hypersensitivity or contraindications to valaciclovir, gadolinium, or any excipients for TGX-007
Contraindication to MRI with gadolinium
Any condition expected to interfere with the intended timing of debulking surgery
Previous non-glioma cancer within 3 years (other than treated squamous/basal cell skin cancer, treated early-stage cervical cancer or treated/biochemically stable, organ confined prostate cancer)
Any other significant disease or disorder which, in the opinion of the Investigator, may put the patient at risk because of participation in the study or may influence the results of the study or the patient's ability to participate in the study
Patients who have participated in another research study involving an investigational product in the past 12 weeks or 5 half-lives of the product
Any psychological, familial, sociological, or geographical consideration potentially hampering compliance with the study protocol and follow up schedule; these conditions should be discussed with the patient before registration in the study
Unwilling to allow their general practitioner, if appropriate, to be notified of participation in the study
Newly diagnosed patients only:
Any prior therapy for glioma
Intended use of tumour treating fields
Recurrent patients only:
Prior toxicities from anti-cancer agents or radiotherapy which have not recovered to ≤Grade 1 severity
