New Microbiota-endocrine Axis in Fructose Malabsorption-caused Visceral Hypersensitivity in Irritable Bowel Syndrome.

Inclusion Criteria

• •For all groups:
• •Patients with IBS defined by current Rome criteria (currently IV)
• •Adult, aged 18 to 75
• •Regulatory criteria :
• •* Membership of a social security scheme
• •* Adult having read and understood the information letter and signed the consent form
• •* Woman of childbearing age with effective contraception for the duration of the study such as oestroprogestins, intrauterine device, tubal ligation, vasectomised partner or sexual abstinence (no heterosexual intercourse for 1 month and a negative urine pregnancy test at inclusion).
• •* Postmenopausal women: confirmatory diagnosis (non-medically induced amenorrhoea for at least 12 months prior to the inclusion visit or biologically documented)
• •* Women of childbearing age who have been rendered surgically infertile (e.g. hysterectomy, bilateral salpingectomy, bilateral oophorectomy).
• •For the IBS group with fructose malabsorption and visceral hypersensitivity (named group of interest, MalF-HyperSens) (1):
• •25g fructose breath test in favour of fructose malabsorption
• •Rectal barostat finding visceral hypersensitivity
• •For the IBS group with fructose malabsorption and without visceral hypersensitivity (known as the MalF-NormoSens group) (2):
• •Fructose breath test at 25g dose in favour of fructose malabsorption
• •Rectal barostat finding no visceral hypersensitivity
• •For the IBS group without fructose malabsorption and visceral hypersensitivity (named NormoF-HyperSens group) (3):
• •Fructose breath test at 25g dose in favour of no fructose malabsorption
• •Rectal barostat finding visceral hypersensitivity
• •For the IBS group without fructose malabsorption or visceral hypersensitivity (called the NormoF-NormoSens group) (4):
• •Fructose breath test at a dose of 25g in favour of the absence of fructose malabsorption
• •Rectal barostat finding no visceral hypersensitivity