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Transcranial Magnetic Stimulation in Veterans With PTSD | Clinical Trials | Clareo Health

RECRUITINGNA

Transcranial Magnetic Stimulation in Veterans With PTSD

Transcranial Magnetic Stimulation in Veterans With PTSD: A Pilot Study to Examine Mechanism of Effect

NCT07336251•White River Junction Veterans Affairs Medical Center

Summary

With this research investigators hope to begin to understand how rTMS can improve posttraumatic stress disorder (PTSD) symptoms. TMS improves PTSD through two interrelated mechanisms: change in brain limbic system function and change in systemic inflammatory activation. Participants who decide to join this study, will receive ten rTMS treatments. All participants will undergo a 40-minute rTMS procedure with a member of the study team 10 times over 2-4 weeks. Participants will undergo fMRI scans of the head in order to help researchers better understand potential effects of rTMS on brain activity. In addition, participants will be asked to give two breath and blood samples to look for signs of general inflammation.

Eligibility

Age

19 - 70 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Age between 19 and 70
•Eligible for VA healthcare
•Moderate to severe PTSD as determined by a total score of at least 25 on the CAPS within 7 days of randomization.
•Agree to have CAPS audio recorded.
•Ability to obtain a Motor Threshold using the TMS device during screening.
•If female with childbearing potential, use of acceptable method of birth control (i.e., use of contraceptives, abstinence).
•Able to read, understand, and sign the informed consent document.

Exclusion Criteria

•Pregnant or lactating woman.
•MRI is contraindicated
•Current use of clozapine (any dose) or bupropion (more than 300mg per day).
•Cardiac pacemaker or implantable defibrillator.
•Presence of any metal object in the head, including cochlear implants, but excluding dental work in the mouth.
•Significant central nervous system disorder (stroke, brain mass, epilepsy).
•Seizure in past one year.
•Current psychosis or mania.
•Significant suicidal ideation.
•Unstable medical conditions.
+9 more criteria

Locations (1)

White River Junction VA Hospital

White River Junction, Vermont, United States

Key Dates

Start Date

January 15, 2026

Primary Completion Date

January 1, 2027

Completion Date

January 1, 2027

Last Updated

January 21, 2026

Enrollment

ESTIMATED participants

Conditions

PTSD - Post Traumatic Stress Disorder

Interventions

Transcranial Magnetic Stimulation

DEVICE

Contacts

Bradley V Watts, MD, MPH

CONTACT

802-295-9363 bradley.watts@va.gov

Julian Sewall

CONTACT

603-266-7140 julian.sewall@va.gov

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 21, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Transcranial Magnetic Stimulation in Veterans With PTSD

Inclusion Criteria

Exclusion Criteria

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