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A Randomized, Multicenter, Open-label Clinical Study Using Peripheral Blood Circulating Tumor DNA to Evaluate the Efficacy of Preoperative Treatment With Pyrotinib + Trastuzumab + Docetaxel Versus Pertuzumab + Trastuzumab + Docetaxel in Early or Locally Advanced HER2-positive Breast Cancer
This study is a randomized, open-label, multicenter clinical study for patients with early or locally advanced (T≥2cm, N0-3, M0) HER2-positive breast cancer, aiming to compare the peripheral blood ctDNA clearance of neoadjuvant pyrotinib + trastuzumab + docetaxel and pertuzumab + trastuzumab + docetaxel for one course and to evaluate the therapeutic effectiveness of four courses of neoadjuvant therapy
Age
18 - 70 years
Sex
FEMALE
Healthy Volunteers
No
Ruijin Hospital
Shanghai, China
Start Date
February 1, 2024
Primary Completion Date
December 31, 2025
Completion Date
December 31, 2026
Last Updated
January 12, 2026
60
ESTIMATED participants
pyrotinib
DRUG
pertuzumab
DRUG
trastuzumab
DRUG
docetaxel
DRUG
Lead Sponsor
Shanghai Jiao Tong University School of Medicine
NCT05372640
NCT04704661
Data Source & Attribution
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