Identifying Biomarkers in ALS Patients Using Neuronal Derived Extracellular Vesicles

Inclusion Criteria

• •For patients :
• •Age ≥ 18 years. Diagnostic suspicion of amyotrophic lateral sclerosis (ALS). Planned inpatient admission in the HFAR neurology department for the standard diagnostic work-up as part of routine care: clinical evaluation, neuropsychological assessment, nerve conduction studies/EMG, motor evoked potentials (TMS/MEP), brain and spinal MRI, pulmonary function testing, lumbar puncture, and standard blood tests.
• •Explicit written informed consent to participate in the study. Affiliation with or beneficiary of a social security system.
• •Patient under legal protection/guardianship. Pregnant or breastfeeding woman. Active infection within the 4 weeks preceding biological sampling. Ongoing diagnosis and management of cancer.
• •Secondary exclusion criterion:
• •ALS diagnosis not confirmed.
• •For Healthy Controls :
• •Age ≥ 18 years. Explicit written informed consent to participate in the study. Affiliation with or beneficiary of a social security system.