o Tadalafil for Prevention of Docetaxel-Induced Peripheral Neuropathy in Prostate Cancer

Exclusion Criteria

• •Pre-existing peripheral neuropathy (CTCAE grade \>= 1).
• •Prior treatment with taxane-based chemotherapy.
• •Concurrent use of nitrates or nitric oxide donors.
• •Severe cardiovascular disease (e.g., unstable angina, recent myocardial infarction within 6 months).
• •Known hypersensitivity to tadalafil or PDE5 inhibitors.