Efficacy of Topical Coenzyme Q10 and Curcumin for Oral Leukoplakia Treatment

Exclusion Criteria

• •Moderate-to-severe dysplasia, carcinoma in situ, or invasive oral cancer.
• •Presence of any visible oral lesions except for oral leukoplakia.
• •Active periodontal diseases as this can confound salivary biomarkers.
• •Significant systemic illness or immunosuppression.
• •Patients who have taken systemic or topical antioxidant supplements within the last four weeks will be excluded to avoid confounding effects on salivary biomarkers.
• •Pregnant and lactating women will be excluded due to hormonal changes that may alter oxidative stress and ethical considerations.
• •Patients unwilling or unable to comply with study requirements.