Nursing-Led Deep Vein Thrombosis Prevention in Neurosurgery

Neurointerdisciplinary Nursing Prevention Strategies for Deep Vein Thrombosis (DVT) After Neurosurgical Procedures: A Multicenter Randomized Controlled Trial and Nomogram Development

NCT07330661•West China Hospital

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to see if a nurse-led program (early movement, leg-sleeve squeezes, and blood tests) can prevent dangerous leg blood clots in adults who have just had brain or spine surgery. Main questions it aims to answer: * Does the program lower the number of clots within 30 days after surgery? * Is the program safer and more accurate than the usual clot-risk score nurses already use? Researchers will compare patients who receive the nurse-led program with patients who receive standard hospital care. Participants will: * Be randomly assigned to one of the two groups. * Have regular leg ultrasounds to check for clots. * Wear a small activity tracker if they are in the nurse-led group.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Age ≥ 18 years
•Any elective or emergency craniotomy, spinal, or other neurosurgical procedure
•Expected post-operative hospital stay ≥ 3 days
•Patient or legally authorized representative willing and able to give written informed consent

Exclusion Criteria

•Pre-operative ultrasound or imaging proven DVT or pulmonary embolism
•Known hereditary bleeding disorder (e.g., hemophilia) or platelet count \< 50 × 10⁹/L
•Chronic therapeutic anticoagulation (warfarin, DOAC, heparin) that cannot be safely stopped, or need for full-dose post-op anticoagulation
•Severe liver disease (Child-Pugh class C) or eGFR \< 30 mL/min/1.73 m²
•Life-limiting co-morbidity with expected survival \< 30 days
•Pregnancy or breastfeeding
•Current participation in another interventional VTE trial

Locations (1)

West China Hospital of Sichuan University

Chengdu, Sichuan, China

Key Dates

Start Date

January 1, 2021

Primary Completion Date

December 30, 2023

Completion Date

May 1, 2024

Last Updated

January 12, 2026

Enrollment

1,286

ACTUAL participants

Conditions

Deep Vein Thrombosis (DVT)

Interventions

nurse-led program (early movement, leg-sleeve squeezes, and blood tests)

BEHAVIORAL

Cleaner Long-tErm Assessment Registry - Venous Insights and Efficacy With eXtended Tracking

NCT07102160

Deep Vein Thrombosis (DVT)Thrombus in the Peripheral Venous Vasculature+2 more

View study

COMPLETED

Improving Emergency Department Testing for Deep Vein Thrombosis

NCT06195787

Deep Vein Thrombosis (DVT)

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 12, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions