Age

45–any

Sex

ALL

Healthy volunteers

Not accepted

1. Age ≥ 45 years
2. A confirmed COPD diagnosis at least 12 months prior to enrollment
3. Stable clinical conditions, defined as no exacerbations or respiratory infections of any severity in the last 3 months before enrollment
4. Moderate to Severe airflow obstruction (FEV1 30-80 %predicted post bronchodilation.
5. No hospitalizations for any cause in the 3 months prior to enrollment
6. Ability to perform repeatable pulmonary function tests
7. Chronic inhaled therapy with LAMA/LABA or LAMA/LABA/ICS with no changes in dosage in the last 3 before enrollment

Immuno-inflammatory Response of Erdosteine in COPD