Tracjectories and Predictors of Chemotherapy Induced Peripheral Neuropathy in Children With Acute Lymphoblastic Leukemia

Exclusion Criteria

• •participating other experimental trials, such as electrical stimulation, exercise therapy may improve CIPN symptoms.
• •with severe complications, including but not limited to significant heart, brain, or lung function failure.
• •had peripheral neuropathy symptoms caused by other diseases like genetic diseases, spinal cord injury.
• •had neuromuscular diseases (e.g., traumatic brain injury and cerebral palsy).
• •had central nervous system cancer or secondary cancer.
• •had multiple treatment like radiotherapy.